Acceptable Tests for the Early Detection of Cancer : A Part from the Book Chapter : Estimation of Low Radiation Doses Effects by Using Tumor Markers

cancer incidence

Over time, the number of RWs who have cancer has increased. There has been evidence of cancer among occupational workers in several recent studies. Chronic low radiation dose exposure results in oxidative stress, increased genomic instability, and an increase in cancer among RWs, according to a study that used human peripheral blood cells to evaluate DNA damage and antioxidant status. Furthermore, compared to the general population, Korean RWs had a greater prevalence of thyroid cancer. Additionally, research on health concerns indicates that cardiac catheterization workers have higher rates of skin lesions overall, orthopedic illnesses, cataracts, hypertension, and hypercholesterolemia. Another study that looked at low-dose cancer mortality risks in the nuclear industry found statistical significance and evidence of stochastic effects for lung cancers. Based on that, it is crucial to provide the population with more intensive and protective measures, safe development tools, and acceptable tests for the early detection of cancer.

Author(s) Details:

Areej Dahdol
Palestinian Ministry of Health, Salfit, Palestine and Department of Medical Imaging, Faculty of Health Professions, Al-Quds University, Jerusalem, Palestine.

Mohammad Hjouj
Department of Medical Imaging, Faculty of Health Professions, Al-Quds University, Jerusalem, Palestine.


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Recent Global Research Developments in Tumor Marker Testing Trends

Current Research Status of Tumor Cell Biomarker Detection: In the quest for early tumor diagnosis and real-time monitoring, biomarkers play a crucial role. These markers can be found in body fluids and include circulating tumor cells, nucleic acids, protein markers, and extracellular vesicles. Among them, circulating tumor cells, circulating tumor DNA, and exosomes offer valuable insights into tumor characteristics and evolution. Researchers have explored various techniques, such as enzyme-linked immunosorbent assays, immunoblotting, and mass spectrometry, to detect these markers. Electrochemical biosensors and fluorescence signal analysis are highly preferred due to their sensitivity, rapid detection, and portability. Recent studies have focused on in situ fluorescence monitoring and analyzing tumor markers in living cells, paving the way for new detection methods [1].

Proteomics Technology and Cancer Biomarkers: Advancements in proteomics technology have significantly improved the identification of clinically relevant biomarkers and therapeutic targets, especially in cancer research. These developments enhance our understanding of cancer and guide targeted therapies [2].

Shifting Paradigm in Cancer Treatment: The landscape of cancer treatment is evolving from relying solely on representative tumor markers for diagnosis and treatment evaluation. Instead, researchers are exploring companion markers for molecular-targeted therapeutics that specifically target cancer cells [3].

References

  1. Jiang, L., Lin, X., Chen, F., Qin, X., Yan, Y., Ren, L., … & Wang, Y. (2023). Current research status of tumor cell biomarker detection. Microsystems & Nanoengineering, 9(1), 123.
  2. Thaddi, B.N., Dabbada, V.B., Ambati, B. et al. Decoding cancer insights: recent progress and strategies in proteomics for biomarker discovery. J Proteins Proteom 15, 67–87 (2024). https://doi.org/10.1007/s42485-023-00121-9
  3. Kikuchi, Y., Shimada, H., Hatanaka, Y. et al. Clinical practice guidelines for molecular tumor markers, 2nd edition review part 1. Int J Clin Oncol 29, 1–19 (2024). https://doi.org/10.1007/s10147-023-02430-x
  4. Hayes, D.F., Sauerbrei, W. & McShane, L.M. REMARK guidelines for tumour biomarker study reporting: a remarkable history. Br J Cancer 128, 443–445 (2023). https://doi.org/10.1038/s41416-022-02046-4

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