Extracellular Signal-Regulated Kinase [ERK]: A Part from The Book Chapter: Multistep Oncogenesis of Adult T-cell Leukemia/ Lymphoma and Significance of Carbon Anhydrase IX Activated via NF-k B and PI3K


Immediately after HTLV-1 infection, expression of many virus-derived components and transactivating proteins is stimulated, and replication of HTLV-1 and proliferation of HTVL-1-infected T-cells are promoted. The main player at the early stage of ATL oncogenesis is Tax. Tax activates several signaling pathways (NF-κB, KRAS/mitogen-activated protein kinase kinase [MEK]/extracellular signal-regulated kinase [ERK], PI3K/AKT/mTOR, and other signaling pathways) and transcriptional activators and co-activators (CBP/p300, AP-1, and others), while Tax inhibits DNA repairs and induces senescence and inhibition of apoptosis. Transcription of Tax is soon suppressed by HBZ, and its expression in primary ATL cells is quite low or suppressed. Thus Tax does not play a major role in completion of ATL oncogenesis. In contrast, NF-κB is expressed at the final stage.

Author(s) Details:

Mitsuru Sakitani,
Institute CCC, Kobe, Hyogo, 651-2242, Japan.

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