Not all SNPs Identified are Deleterious and it is Important to Distinguish Deleterious SNPs : A Part from the Book Chapter : An In silico Analysis of Deleterious Single Nucleotide Polymorphisms of Human Lysozyme C Gene

Not all SNPs identified are deleterious and it is important to distinguish deleterious SNPs from neutral SNPs. Due to the large number of SNPs, it is challenging to conduct laboratory tests to determine the significance and biological contribution of each SNP. However, computational tools can be used to initially filter potentially damaging SNPs that might affect susceptibility to diseases and drug metabolism before further laboratory investigations. This study analyzed missense nsSNPs of LYZ C gene and the effect of variants on the protein’s three-dimensional structure and function.

Author(s) Details:

Harini Venkata Subbiah
Human Genetics Research Centre, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, 600100, India.

Usha Subbiah
Human Genetics Research Centre, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai, Tamil Nadu, 600100, India.

Also See : The spread of drug resistant pathogens is one of the most serious threats to successful treatment of microbial diseases : A Part from The Book : Isolation and Phytochemical Identification of Antibacterial Bioactive Components

Recent Global Research Developments in Single Nucleotide Polymorphisms: A Comprehensive Overview of Genetic Variation

SNP Arrays in Aquaculture: Recent advancements in SNP arrays have significantly improved the genetic characteristics of aquatic species. These arrays are used for genome-wide association studies (GWAS) and genomic selection, enhancing traits such as growth rate and disease resistance [1] .

SNP Biosensors: There has been notable progress in the development of SNP biosensors, which are crucial for clinical diagnostics. These biosensors utilize fluorescent and electrochemical methods to detect SNPs with high specificity and sensitivity [2] .

Human Genetic Variation: Genome-wide scans of SNPs have identified new susceptibility variants for common diseases and provided insights into the genetic structure of human populations [3] .

DNA Methylation and SNPs: Research has highlighted the impact of SNPs on DNA methylation, which affects gene expression and can influence disease susceptibility. This area of study is crucial for understanding the genetic basis of epigenetic changes [4] .

SNPs in Personalized Medicine: SNPs play a significant role in personalized medicine by influencing drug response and disease risk. Studies have focused on both synonymous and non-synonymous SNPs and their effects on protein function and therapeutic outcomes [5] .

References

1. Rasal, K.D., Kumar, P.V., Asgolkar, P. et al. Single-Nucleotide Polymorphism (SNP) array: an array of hope for genetic improvement of aquatic species and fisheries management. Blue Biotechnology 1, 3 (2024). https://doi.org/10.1186/s44315-024-00004-8
2. Wu K, Kong F, Zhang J, Tang Y, Chen Y, Chao L, Nie L, Huang Z. Recent Progress in Single-Nucleotide Polymorphism Biosensors. Biosensors. 2023; 13(9):864. https://doi.org/10.3390/bios13090864
3. López Herráez D, Bauchet M, Tang K, Theunert C, Pugach I, Li J, et al. (2009) Genetic Variation and Recent Positive Selection in Worldwide Human Populations: Evidence from Nearly 1 Million SNPs. PLoS ONE 4(11): e7888. https://doi.org/10.1371/journal.pone.0007888
4. Villicaña, S., Bell, J.T. Genetic impacts on DNA methylation: research findings and future perspectives. Genome Biol 22, 127 (2021). https://doi.org/10.1186/s13059-021-02347-6
5. Single Nucleotide Polymorphisms
   https://link.springer.com/book/10.1007/978-3-031-05616-1

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