AD is an aging brain pathology, and maybe it is a combination of different diseases or various symptoms that are orchestrated in common.
Researches have not yet found a convincing explanation of the dilemma of the underlying pathogenesis of AD and they come to understand that the underpinning etiology of the disease is heterogenous and might be a package of illnesses that actually embrace different categories of diseases, each with its own underpinning biology and each, perhaps, requiring a specific therapeutic intervention strategy.
From another point of view, far from the prevailing thought, that cholinergic theory, Aβ cascade hypothesis or abnormally excessive phosphorylated Tau protein are the only main pathogenesis of AD, other opinions come from many scientists who have focused on another etiology, or alternative theory, that depends on more central factors that may underpinning the pathogenesis of AD and other dementias: attention toward the immune system saying that “Impairment of the immune system (Immunosenescence) maybe implicated deeply in the pathogenesis of AD”.
Author(s) Details:
Abdalla Bowirrat
Department of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel 40700, Israel.
Aia Bowirrat M. D.
Department of Orthopedic Surgery, Hasharon Hospital, Rabin Medical Center, Petah Tikwa, Israel.
Recent Global Research Developments in Alzheimer’s Disease: A Complex, Multifactorial Disorder
Recent Advances in Alzheimer’s Disease: Mechanisms, Clinical Trials, and New Drug Development Strategies – This review discusses the current understanding of Alzheimer’s disease pathogenesis, advances in diagnostic biomarkers, the latest updates on clinical trials, and emerging technologies for drug development [1] .
Alzheimer’s is a Multifactorial Disease – This book chapter explores the diverse facets of disease mechanisms underlying Alzheimer’s, emphasizing the need for multipronged strategies to develop effective diagnostic tools and treatment options [2] .
Dissecting Complex and Multifactorial Nature of Alzheimer’s Disease – This article reviews established etiological mechanisms, including the roles of beta-amyloid and apolipoprotein E (APOE), along with newer factors like epigenetic modifications[3] .
Alzheimer’s Disease: Epidemiology and Clinical Progression – This review provides insights into the epidemiology of Alzheimer’s disease and its progression, based on literature from North America, Europe, and Asia [4] .
Recent Advances on Drug Development and Emerging Therapeutic Agents for Alzheimer’s Disease – This article covers recent advances in drug development and emerging therapeutic agents targeting different aspects of Alzheimer’s disease [5] .
References
- Zhang, J., Zhang, Y., Wang, J., Xia, Y., Zhang, J., & Chen, L. (2024). Recent advances in Alzheimer’s disease: Mechanisms, clinical trials and new drug development strategies. Signal Transduction and Targeted Therapy, 9(1), 211.
- Samanta, S., Ramesh, M., & Govindaraju, T. (2022). Alzheimer’s is a Multifactorial Disease.
- Talwar, P., Sinha, J., Grover, S. et al. Dissecting Complex and Multifactorial Nature of Alzheimer’s Disease Pathogenesis: a Clinical, Genomic, and Systems Biology Perspective. Mol Neurobiol 53, 4833–4864 (2016). https://doi.org/10.1007/s12035-015-9390-0
- Tahami Monfared, A.A., Byrnes, M.J., White, L.A. et al. Alzheimer’s Disease: Epidemiology and Clinical Progression. Neurol Ther 11, 553–569 (2022). https://doi.org/10.1007/s40120-022-00338-8
- Athar, T., Al Balushi, K., & Khan, S. A. (2021). Recent advances on drug development and emerging therapeutic agents for Alzheimer’s disease. Molecular biology reports, 48(7), 5629-5645.
