Author(s) Details:
Khaled Jadallah
Department of Internal Medicine, King Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Roberto De Giorgio
Department of Translational Sciences, University of Ferrara, Ferrara, Italy.
Rami Jadallah
Department of Internal Medicine, King Abdullah University Hospital, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
This section is a part of the chapter: Pharmacological Ad-vancements in the Management of Constipation-Predominant Irritable Bowel Syndrome: A Comprehensive Review
Most patients with IBS-C are often older adults or come from lower socioeconomic backgrounds (Sperber et al. 2021, Yazbeck et al. 2023, Bosman et al. 2023, Silvernale et al. 2019). Recent studies have shown that IBS-C is associated with higher rates of functional impairment compared to other IBS subtypes (5) IBS-C has been identified as the clinical phenotype that exerts the greatest financial impact on the U.S. healthcare system (Lacy et al. 2024). A study conducted by Shin et al. employed a retrospective cohort analysis of administrative health claims data to evaluate annual healthcare utilization across the various subtypes of IBS over a five-year period (Shin and Xu 2024). The analysis revealed that the total healthcare costs for patients with IBS-C (N=23,923) amounted to $16,005 (interquartile range [IQR] $6,384–$43,972) for all causes and $2,222 (IQR $511–$7,884) related explicitly to IBS. In comparison, patients with IBS-D (n=33,947), IBS-M (n=18,052), and IBS-U (n=26,965) incurred all-cause costs ranging from $11,996 to $13,542 and IBS-specific costs from $756 to $1,214. The elevated costs associated with IBS-C are largely attributable to a higher frequency of emergency room visits, an increased need of radiological tests, and hospitalization rates among these patients..
How to Cite
Jadallah, K., Giorgio, R. D., & Jadallah, R. (2025). Pharmacological Advancements in the Management of Constipation-Predominant Irritable Bowel Syndrome: A Comprehensive Review. Medical Science: Trends and Innovations Vol. 4, 49–85. https://doi.org/10.9734/bpi/msti/v4/4177