The Recent Busselton Health Study in Busselton, Western Australia, Demonstrated that a High BMI was a Risk Factor for AF Independent of Hypertension and more Predictive of AF in Men : A Part from The Book Chapter : Unraveling the Nexus between Obesity and Atrial Fibrillation: Mechanistic Insights and Clinical Implications

Hypertension

Obesity is often associated with hypertension, metabolic syndrome, and obstructive sleep apnea (OSA). Multiple studies evaluated the impact of these conditions as confounders on obesity-promoted AF development. In a retrospective cohort of 389,321 individuals, Lee et al. reported that metabolically healthy obesity was associated with a 20% increased risk of AF, whereas a 40% increase in the risk of AF was associated with metabolically unhealthy obesity. Gami et al. demonstrated that obesity predicts AF independently of OSA syndrome. A 1-unit increase in BMI was associated with a 7% increased AF risk (95% confidence interval, 5–10%); however, obesity did not independently predict AF incidence in older adults (≥65 years). The recent Busselton Health Study in Busselton, Western Australia, demonstrated that a high BMI was a risk factor for AF independent of hypertension and more predictive of AF in men.

Author(s) Details:

Hongyang Shu,
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China and Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiologic Disorders, Huazhong University of Science and Technology, Wuhan 430000, China.

Jia Cheng,
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China and Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiologic Disorders, Huazhong University of Science and Technology, Wuhan 430000, China.

Na Li,
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China and Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiologic Disorders, Huazhong University of Science and Technology, Wuhan 430000, China.

Zixuan Zhang,
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China and Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiologic Disorders, Huazhong University of Science and Technology, Wuhan 430000, China.

Jiali Nie,
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China and Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiologic Disorders, Huazhong University of Science and Technology, Wuhan 430000, China.

Yizhong Peng,
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China.

Yan Wang,
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China and Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiologic Disorders, Huazhong University of Science and Technology, Wuhan 430000, China.

Dao Wen Wang,
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China and Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiologic Disorders, Huazhong University of Science and Technology, Wuhan 430000, China.

Ning Zhou,
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430000, China and Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiologic Disorders, Huazhong University of Science and Technology, Wuhan 430000, China.

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